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Target
Cannabinoid receptor 1
Ligand
BDBM50298917
Substrate
n/a
Meas. Tech.
ChEMBL_588141 (CHEMBL1049258)
Ki
41±n/a nM
Citation
 Silvestri, R; Ligresti, A; La Regina, G; Piscitelli, F; Gatti, V; Brizzi, A; Pasquini, S; Lavecchia, A; Allarà, M; Fantini, N; Carai, MA; Novellino, E; Colombo, G; Di Marzo, V; Corelli, F Synthesis, cannabinoid receptor affinity, molecular modeling studies and in vivo pharmacological evaluation of new substituted 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides. 2. Effect of the 3-carboxamide substituent on the affinity and selectivity profile. Bioorg Med Chem 17:5549-64 (2009) [PubMed]  Article 
Target
Name:
Cannabinoid receptor 1
Synonyms:
CANN6 | CANNABINOID CB1 | CB-R | CB1 | CNR | CNR1 | CNR1_HUMAN | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cannabinoid receptor 1 (brain)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
52868.96
Organism:
Homo sapiens (Human)
Description:
P21554
Residue:
472
Sequence:
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
  
Inhibitor
Name:
BDBM50298917
Synonyms:
CHEMBL574036 | N-[2-(2,4-Dichlorophenyl)ethyl]1-(2,4-difluorophenyl)-5-(2,5-dimethyl-1H-pyrrol-1-yl)-4-methyl-1H-pyrazole-3-carboxamide
Type:
Small organic molecule
Emp. Form.:
C25H22Cl2F2N4O
Mol. Mass.:
503.371
SMILES:
Cc1ccc(C)n1-c1c(C)c(nn1-c1ccc(F)cc1F)C(=O)NCCc1ccc(Cl)cc1Cl |(30.24,-27.27,;29.77,-25.8,;30.67,-24.56,;29.77,-23.31,;28.3,-23.78,;27.06,-22.88,;28.3,-25.32,;27.06,-26.23,;25.59,-25.75,;25.12,-24.3,;24.68,-27.01,;25.59,-28.25,;27.06,-27.77,;28.3,-28.68,;29.71,-28.05,;30.95,-28.96,;30.79,-30.49,;32.03,-31.39,;29.38,-31.11,;28.14,-30.21,;26.74,-30.83,;23.14,-27.01,;22.37,-25.68,;22.37,-28.33,;20.83,-28.33,;20.06,-29.66,;18.52,-29.66,;17.75,-28.33,;16.21,-28.33,;15.44,-29.66,;13.9,-29.66,;16.21,-31,;17.75,-31,;18.52,-32.34,)|
Structure:
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