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Target
Vasopressin V1b receptor
Ligand
BDBM50299357
Substrate
n/a
Meas. Tech.
ChEMBL_590268 (CHEMBL1052803)
Ki
227±n/a nM
Citation
 Scott, JD; Miller, MW; Li, SW; Lin, SI; Vaccaro, HA; Hong, L; Mullins, DE; Guzzi, M; Weinstein, J; Hodgson, RA; Varty, GB; Stamford, AW; Chan, TY; McKittrick, BA; Greenlee, WJ; Priestley, T; Parker, EM Tetrahydroquinoline sulfonamides as vasopressin 1b receptor antagonists. Bioorg Med Chem Lett 19:6018-22 (2009) [PubMed]  Article 
Target
Name:
Vasopressin V1b receptor
Synonyms:
Avpr1b | V1BR_RAT | VASOPRESSIN V1B | Vasopressin V1b receptor | Vasopressin receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
47104.48
Organism:
RAT
Description:
VASOPRESSIN V1B AVPR1B RAT::P48974
Residue:
425
Sequence:
MNSEPSWTATPSPGGTLPVPNATTPWLGRDEELAKVEIGILATVLVLATGGNLAVLLTLGRHGHKRSRMHLFVLHLALTDLGVALFQVLPQLLWDITYRFQGSDLLCRAVKYLQVLSMFASTYMLLAMTLDRYLAVCHPLRSLRQPSQSTYPLIAAPWLLAAILSLPQVFIFSLREVIQGSGVLDCWADFYFSWGPRAYITWTTMAIFVLPVAVLSACYGLICHEIYKNLKVKTQAGREERRGWRTWDKSSSSAVATAATRGLPSRVSSISTISRAKIRTVKMTFVIVLAYIACWAPFFSVQMWSVWDENAPNEDSTNVAFTISMLLGNLSSCCNPWIYMGFNSRLLPRSLSHHACCTGSKPQVHRQLSTSSLTSRRTTLLTHACGSPTLRLSLNLSLRAKPRPAGSLKDLEQVDGEATMETSIF
  
Inhibitor
Name:
BDBM50299357
Synonyms:
1-(2-(1-(2,4-dimethoxyphenylsulfonyl)-1,2,3,4-tetrahydroquinolin-2-yl)ethylsulfonyl)-N-propylpiperidin-4-amine | CHEMBL575987
Type:
Small organic molecule
Emp. Form.:
C27H39N3O6S2
Mol. Mass.:
565.745
SMILES:
CCCNC1CCN(CC1)S(=O)(=O)CCC1CCc2ccccc2N1S(=O)(=O)c1ccc(OC)cc1OC
Structure:
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