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Target
Malate dehydrogenase, mitochondrial
Ligand
BDBM7307
Substrate
n/a
Meas. Tech.
ChEMBL_593431 (CHEMBL1041437)
IC50
2400±n/a nM
Citation
 Becker, A; Kohfeld, S; Lader, A; Preu, L; Pies, T; Wieking, K; Ferandin, Y; Knockaert, M; Meijer, L; Kunick, C Development of 5-benzylpaullones and paullone-9-carboxylic acid alkyl esters as selective inhibitors of mitochondrial malate dehydrogenase (mMDH). Eur J Med Chem 45:335-42 (2010) [PubMed]  Article 
Target
Name:
Malate dehydrogenase, mitochondrial
Synonyms:
MDH2 | MDHM_HUMAN
Type:
PROTEIN
Mol. Mass.:
35512.45
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1456625
Residue:
338
Sequence:
MLSALARPASAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIETKAAVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATLTAACAQHCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTFVAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLTALTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIEKNLGIGKVSSFEEKMISDAIPELKASIKKGEDFVKTLK
  
Inhibitor
Name:
BDBM7307
Synonyms:
5-benzyl-9-bromopaullone | 8-benzyl-14-bromo-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,17}]octadeca-1(11),2,4,6,12(17),13,15-heptaen-9-one | CHEMBL99779 | NSC 702377 | Paullone Analog 46
Type:
Small organic molecule
Emp. Form.:
C23H17BrN2O
Mol. Mass.:
417.298
SMILES:
Brc1ccc2[nH]c-3c(CC(=O)N(Cc4ccccc4)c4ccccc-34)c2c1
Structure:
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