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Target
HTH-type transcriptional regulator ExsA
Ligand
BDBM50378357
Substrate
n/a
Meas. Tech.
ChEMBL_592474 (CHEMBL1043190)
IC50
3500±n/a nM
Citation
 Kim, OK; Garrity-Ryan, LK; Bartlett, VJ; Grier, MC; Verma, AK; Medjanis, G; Donatelli, JE; Macone, AB; Tanaka, SK; Levy, SB; Alekshun, MN N-hydroxybenzimidazole inhibitors of the transcription factor LcrF in Yersinia: novel antivirulence agents. J Med Chem 52:5626-34 (2009) [PubMed]  Article 
Target
Name:
HTH-type transcriptional regulator ExsA
Synonyms:
EXSA_PSEAE | Exoenzyme S synthesis regulatory protein exsA | exsA
Type:
PROTEIN
Mol. Mass.:
31648.37
Organism:
Pseudomonas aeruginosa
Description:
ChEMBL_635526
Residue:
278
Sequence:
MQGAKSLGRKQITSCHWNIPTFEYRVNKEEGVYVLLEGELTVQDIDSTFCLAPGELLFVRRGSYVVSTKGKDSRILWIPLSAQFLQGFVQRFGALLSEVERCDEPVPGIIAFAATPLLAGCVKGLKELLVHEHPPMLACLKIEELLMLFAFSPQGPLLMSVLRQLSNRHVERLQLFMEKHYLNEWKLSDFSREFGMGLTTFKELFGSVYGVSPRAWISERRILYAHQLLLNSDMSIVDIAMEAGFSSQSYFTQSYRRRFGCTPSRSRQGKDECRAKNN
  
Inhibitor
Name:
BDBM50378357
Synonyms:
CHEMBL575329
Type:
Small organic molecule
Emp. Form.:
C22H15FN4O4
Mol. Mass.:
418.3773
SMILES:
On1c(nc2ccc(cc12)[N+]([O-])=O)-c1ccc(NC(=O)\C=C\c2ccc(F)cc2)cc1
Structure:
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