Reaction Details Report a problem with these data
Target
Lipoxygenase
Ligand
BDBM50303170
Substrate
n/a
Meas. Tech.
ChEMBL_594906 (CHEMBL1040777)
IC50
280±n/a nM
Citation
 Chowdhury, MA; Abdellatif, KR; Dong, Y; Das, D; Yu, G; Velázquez, CA; Suresh, MR; Knaus, EE Synthesis and biological evaluation of salicylic acid and N-acetyl-2-carboxybenzenesulfonamide regioisomers possessing a N-difluoromethyl-1,2-dihydropyrid-2-one pharmacophore: dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity. Bioorg Med Chem Lett 19:6855-61 (2009) [PubMed]  Article 
Target
Name:
Lipoxygenase
Synonyms:
5-Lipoxygenase | 5-Lipoxygenase (5-LO)
Type:
Enzyme
Mol. Mass.:
97294.59
Organism:
Solanum tuberosum (potato)
Description:
n/a
Residue:
864
Sequence:
MNIGQIMGGRELFGGHDDSKKVKGTVVMMKKNALDFTDLAGSLTDIAFDVLGQKVSFQLISSVQGDPTNGLQGKHSNPAYLENSLFTLTPLTAGSETAFGVTFDWNEEFGVPGAFIIKNTHINEFFLKSLTLEDVPNHGKVHFDCNSWVYPSFRYKSDRIFFANQPYLPSKTPELLRKYRENELLTLRGDGTGKREAWDRIYDYDIYNDLGNPDQGKENVRTTLGGSAEYPYPRRGRTGRPPTRTDPKSESRIPLLLSLDIYVPRDERFGHLKMSDFLTYALKSIVQFILPELHALFDGTPNEFDSFEDVLRLYEGGIKLPQGPLFKALTAAIPLEMIKELLRTDGEGILRFPTPLVIKDSKTAWRTDEEFAREMLAGVNPIIISRLQEFPPKSKLDPEAYGNQNSTITAEHIEDKLDGLTVDEAMNNNKLFILNHHDLLIPYLRRINTTITKSYASRTLLFLQDNGSLKPLAIELSLPHPDGDQFGVTSKVYTPSDQGVESSIWQLAKAYVAVNDAGVHQLISHWLNTHAVIEPFVIATNRQLSVLHPIHKLLYPHFRDTMNINASARQILINAGGVLESTVFQSKFALEMSAVVYKDWVFPDQALPADLVKRGVAVEDSSSPHGVRLLIEDYPYAVDGLEIWSAIKSWVTDYCSFYYGSDEEILKDNELQAWWKELREVGHGDKKNEPWWPEMETPQELIDSCTTIIWIASALHAAVNFGQYPYAGYLPNRPTVSRRFMPEPGTPEYEELKKNPDKAFLKTITAQLQTLLGVSLVEILSRHTTDEIYLGQRESPEWTKDKEPLAAFDKFGKKLTDIEKQIIQRNGDNILTNRSGPVNAPYTLLFPTSEGGLTGKGIPNSVSI
  
Inhibitor
Name:
BDBM50303170
Synonyms:
CHEMBL579022 | N-Acetyl-5-(N-difluoromethyl-1,2-dihydropyrid-2-one-4-yl)-2-carboxybenzenesulfonamide
Type:
Small organic molecule
Emp. Form.:
C15H12F2N2O6S
Mol. Mass.:
386.327
SMILES:
CC(=O)NS(=O)(=O)c1cc(ccc1C(O)=O)-c1ccn(C(F)F)c(=O)c1
Structure:
Search PDB for entries with ligand similarity: