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Target
Transporter
Ligand
BDBM50303312
Substrate
n/a
Meas. Tech.
ChEMBL_595538 (CHEMBL1048773)
Ki
996±n/a nM
Citation
 Kaur, H; Izenwasser, S; Verma, A; Wade, D; Housman, A; Stevens, ED; Mobley, DL; Trudell, ML Synthesis and monoamine transporter affinity of 3alpha-arylmethoxy-3beta-arylnortropanes. Bioorg Med Chem Lett 19:6865-8 (2009) [PubMed]  Article 
Target
Name:
Transporter
Synonyms:
NE transporter | NET | Norepinephrine transporter(NET)
Type:
Multi-pass membrane protein
Mol. Mass.:
69236.90
Organism:
Rattus norvegicus (rat)
Description:
Q63380
Residue:
617
Sequence:
MLLARMKPQVQPELGGADQLPEQPLRPCKTADLLVVKERNGVQCLLASQDGDAQPRETWGKEIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQFNREGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFASFTLNLPWTNCGHAWNSPNCTDPKLLNASVLGDHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLCLMVVIVVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSTINCVTSFISGFAIFSILGYMAHEHKVKIEDVATEGAGLVFVLYPEAISTLSGSTFWAVLFFLMLLALGLDSSMGGMEAVITGLADDFQVLKRHRKLFTCAVTLGTFLLAMFCITKGGIYVLTLLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFKPGLYWRLCWKFVSPAFLLFVVVVSIINFKPLTYDDYVYPPWANWVGWGIALSSMILVPAYVIYKFFSIRGSLWERVAYGITPENEHHLVAQRDVRQFQLRHWLAI
  
Inhibitor
Name:
BDBM50303312
Synonyms:
3-alpha-(4-Dichlorophenyl)methoxy-3-beta-phenyl-nortropane | CHEMBL585282
Type:
Small organic molecule
Emp. Form.:
C20H21Cl2NO
Mol. Mass.:
362.293
SMILES:
Clc1ccc(COC2(CC3CCC(C2)N3)c2ccccc2)cc1Cl |TLB:6:7:14:10.11,THB:15:7:14:10.11|
Structure:
Search PDB for entries with ligand similarity: