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Target
5-hydroxytryptamine receptor 6
Ligand
BDBM50304001
Substrate
n/a
Meas. Tech.
ChEMBL_595424 (CHEMBL1040065)
Ki
5±n/a nM
Citation
 de la Fuente, T; Martín-Fontecha, M; Sallander, J; Benhamú, B; Campillo, M; Medina, RA; Pellissier, LP; Claeysen, S; Dumuis, A; Pardo, L; López-Rodríguez, ML Benzimidazole derivatives as new serotonin 5-HT6 receptor antagonists. Molecular mechanisms of receptor inactivation. J Med Chem 53:1357-69 (2010) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 6
Synonyms:
5-HT6 | 5-hydroxytryptamine receptor 6 | 5HT6R_MOUSE | Htr6
Type:
Enzyme Catalytic Domain
Mol. Mass.:
47012.98
Organism:
MOUSE
Description:
5-HT6 HTR6 MOUSE::Q9R1C8
Residue:
440
Sequence:
MVPEPGPVNSSTPAWGPGPPPAPGGSGWVAAALCVVIVLTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTAPRALALILGAWSLAALASFLPLLLGWHELGKARTSAPGQCRLLASLPYVLVASGVTFFLPSGAICFTYCRILLAARKQAVQVASLTTGTATAGQALETLQVPRTPRPGMESADSRRLTTKHSRKALKASLTLGILLSMFFVTWLPFFVASIAQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFVPCVHCPPEHRASPASPSMWTSHSGARPGLSLQQVLPLPLPPNSDSDSASGGTSGLQLTAQLLLPGEATRDPPPPTRAPTVVNFFVTDSVEPEIRQHPLGSPMN
  
Inhibitor
Name:
BDBM50304001
Synonyms:
CHEMBL584690 | [4-(4-Methylpiperazin-1-yl)-1H-benzimidazol-2-yl](1-naphthyl)methanone
Type:
Small organic molecule
Emp. Form.:
C23H22N4O
Mol. Mass.:
370.447
SMILES:
CN1CCN(CC1)c1cccc2[nH]c(nc12)C(=O)c1cccc2ccccc12
Structure:
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