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Target
NAD-dependent protein deacetylase HST2
Ligand
BDBM50304356
Substrate
n/a
Meas. Tech.
ChEMBL_606799 (CHEMBL1067344)
IC50
14500±n/a nM
Citation
 Sanders, BD; Jackson, B; Brent, M; Taylor, AM; Dang, W; Berger, SL; Schreiber, SL; Howitz, K; Marmorstein, R Identification and characterization of novel sirtuin inhibitor scaffolds. Bioorg Med Chem 17:7031-41 (2009) [PubMed]  Article 
Target
Name:
NAD-dependent protein deacetylase HST2
Synonyms:
HST2 | HST2_YEAST | NAD-dependent deacetylase HST2
Type:
PROTEIN
Mol. Mass.:
39972.79
Organism:
Saccharomyces cerevisiae
Description:
ChEMBL_533704
Residue:
357
Sequence:
MSVSTASTEMSVRKIAAHMKSNPNAKVIFMVGAGISTSCGIPDFRSPGTGLYHNLARLKLPYPEAVFDVDFFQSDPLPFYTLAKELYPGNFRPSKFHYLLKLFQDKDVLKRVYTQNIDTLERQAGVKDDLIIEAHGSFAHCHCIGCGKVYPPQVFKSKLAEHPIKDFVKCDVCGELVKPAIVFFGEDLPDSFSETWLNDSEWLREKITTSGKHPQQPLVIVVGTSLAVYPFASLPEEIPRKVKRVLCNLETVGDFKANKRPTDLIVHQYSDEFAEQLVEELGWQEDFEKILTAQGGMGDNSKEQLLEIVHDLENLSLDQSEHESADKKDKKLQRLNGHDSDEDGASNSSSSQKAAKE
  
Inhibitor
Name:
BDBM50304356
Synonyms:
2-methyl-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxamide | CHEMBL611953
Type:
Small organic molecule
Emp. Form.:
C15H18N2O
Mol. Mass.:
242.3162
SMILES:
Cc1ccc2[nH]c3C(CCCCc3c2c1)C(N)=O
Structure:
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