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Target
NAD-dependent protein deacetylase HST2
Ligand
BDBM50304355
Substrate
n/a
Meas. Tech.
ChEMBL_606804 (CHEMBL1068568)
Ki
2500±n/a nM
Citation
 Sanders, BD; Jackson, B; Brent, M; Taylor, AM; Dang, W; Berger, SL; Schreiber, SL; Howitz, K; Marmorstein, R Identification and characterization of novel sirtuin inhibitor scaffolds. Bioorg Med Chem 17:7031-41 (2009) [PubMed]  Article 
Target
Name:
NAD-dependent protein deacetylase HST2
Synonyms:
HST2 | HST2_YEAST | NAD-dependent deacetylase HST2
Type:
PROTEIN
Mol. Mass.:
39972.79
Organism:
Saccharomyces cerevisiae
Description:
ChEMBL_533704
Residue:
357
Sequence:
MSVSTASTEMSVRKIAAHMKSNPNAKVIFMVGAGISTSCGIPDFRSPGTGLYHNLARLKLPYPEAVFDVDFFQSDPLPFYTLAKELYPGNFRPSKFHYLLKLFQDKDVLKRVYTQNIDTLERQAGVKDDLIIEAHGSFAHCHCIGCGKVYPPQVFKSKLAEHPIKDFVKCDVCGELVKPAIVFFGEDLPDSFSETWLNDSEWLREKITTSGKHPQQPLVIVVGTSLAVYPFASLPEEIPRKVKRVLCNLETVGDFKANKRPTDLIVHQYSDEFAEQLVEELGWQEDFEKILTAQGGMGDNSKEQLLEIVHDLENLSLDQSEHESADKKDKKLQRLNGHDSDEDGASNSSSSQKAAKE
  
Inhibitor
Name:
BDBM50304355
Synonyms:
3,4,6-trichloro-2-(2,5-dichloro-6-hydroxy-3-methylbenzyl)phenol | CHEMBL594863
Type:
Small organic molecule
Emp. Form.:
C14H9Cl5O2
Mol. Mass.:
386.485
SMILES:
Cc1cc(Cl)c(O)c(Cc2c(O)c(Cl)cc(Cl)c2Cl)c1Cl
Structure:
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