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Target
Glucocorticoid receptor
Ligand
BDBM50049508
Substrate
n/a
Meas. Tech.
ChEMBL_624272 (CHEMBL1106116)
Ki
1036±n/a nM
Citation
 Onnis, V; Kinsella, GK; Carta, G; Jagoe, WN; Price, T; Williams, DC; Fayne, D; Lloyd, DG Virtual screening for the identification of novel nonsteroidal glucocorticoid modulators. J Med Chem 53:3065-74 (2010) [PubMed]  Article 
Target
Name:
Glucocorticoid receptor
Synonyms:
GCR_HUMAN | GR | GRL | Glucocorticoid | Glucocorticoid receptor (GRFP) | NR3C1 | Nuclear receptor subfamily 3 group C member 1
Type:
Enzyme
Mol. Mass.:
85656.87
Organism:
Homo sapiens (Human)
Description:
P04150
Residue:
777
Sequence:
MDSKESLTPGREENPSSVLAQERGDVMDFYKTLRGGATVKVSASSPSLAVASQSDSKQRRLLVDFPKGSVSNAQQPDLSKAVSLSMGLYMGETETKVMGNDLGFPQQGQISLSSGETDLKLLEESIANLNRSTSVPENPKSSASTAVSAAPTEKEFPKTHSDVSSEQQHLKGQTGTNGGNVKLYTTDQSTFDILQDLEFSSGSPGKETNESPWRSDLLIDENCLLSPLAGEDDSFLLEGNSNEDCKPLILPDTKPKIKDNGDLVLSSPSNVTLPQVKTEKEDFIELCTPGVIKQEKLGTVYCQASFPGANIIGNKMSAISVHGVSTSGGQMYHYDMNTASLSQQQDQKPIFNVIPPIPVGSENWNRCQGSGDDNLTSLGTLNFPGRTVFSNGYSSPSMRPDVSSPPSSSSTATTGPPPKLCLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRYRKCLQAGMNLEARKTKKKIKGIQQATTGVSQETSENPGNKTIVPATLPQLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMFLMAFALGWRSYRQSSANLLCFAPDLIINEQRMTLPCMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVPKDGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHEVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQK
  
Inhibitor
Name:
BDBM50049508
Synonyms:
5-Bromo-4-methoxy-2-((1S,4R)-2,2,4-trimethyl-6-methylene-cyclohexylmethyl)-phenol | 5-bromo-4-methoxy-2-(((1S,4R)-2,2,4-trimethyl-6-methylenecyclohexyl)methyl)phenol | CHEMBL53549
Type:
Small organic molecule
Emp. Form.:
C18H25BrO2
Mol. Mass.:
353.294
SMILES:
COc1cc(C[C@@H]2C(=C)C[C@H](C)CC2(C)C)c(O)cc1Br
Structure:
Search PDB for entries with ligand similarity: