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Target
Bombesin receptor subtype-3
Ligand
BDBM50317460
Substrate
n/a
Meas. Tech.
ChEMBL_631838 (CHEMBL1111909)
EC50
10000±n/a nM
Citation
 Guo, C; Guzzo, PR; Hadden, M; Sargent, BJ; Yet, L; Kan, Y; Palyha, O; Kelly, TM; Guan, X; Rosko, K; Gagen, K; Metzger, JM; Dragovic, J; Lyons, K; Lin, LS; Nargund, RP Synthesis of 7-benzyl-5-(piperidin-1-yl)-6,7,8,9-tetrahydro-3H-pyrazolo[3,4-c][2,7]naphthyridin-1-ylamine and its analogs as bombesin receptor subtype-3 agonists. Bioorg Med Chem Lett 20:2785-9 (2010) [PubMed]  Article 
Target
Name:
Bombesin receptor subtype-3
Synonyms:
BRS3_RAT | Bombesin | Brs3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44213.49
Organism:
RAT
Description:
Bombesin 0 RAT::Q8K418
Residue:
399
Sequence:
MSQRQPQSPNQTLISITNDTETSSSAVSNDTTPKGWTGDNSPGIEALCAIYITYAVIISVGILGNAILIKVFFKTKSMQTVPNIFITSLAFGDLLLLLTCVPVDATHYLAEGWLFGKVGCKVLSFIRLTSVGVSVFTLTILSADRYKAVVKPLERQPSNAILKTCAKAGGIWIMAMIFALPEAIFSNVYTFQDPNRNVTFESCNSYPISERLLQEIHSLLCFLVFYIIPLSIISVYYSLIARTLYKSTLNIPTEEQSHARKQIESRKRIAKTVLVLVALFALCWLPNHLLYLYHSFTYESYAEPSDVPFVVTIFSRVLAFSNSCVNPFALYWLSKTFQKHFKAQLCCFKAEQPEPPLGDTPLNNLTVMGRVPATGSAHVSEISVTLFSGSTAKKGEDKV
  
Inhibitor
Name:
BDBM50317460
Synonyms:
7-isobutyl-5-(piperidin-1-yl)-6,7,8,9-tetrahydro-3H-pyrazolo[3,4-c][2,7]naphthyridin-1-amine | CHEMBL1096548
Type:
Small organic molecule
Emp. Form.:
C18H28N6
Mol. Mass.:
328.4551
SMILES:
CC(C)CN1CCc2c(C1)c(nc1[nH]nc(N)c21)N1CCCCC1
Structure:
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