Reaction Details Report a problem with these data
Target
Nuclear factor NF-kappa-B p105 subunit
Ligand
BDBM50317858
Substrate
n/a
Meas. Tech.
ChEMBL_629937 (CHEMBL1109181)
IC50
>10000±n/a nM
Citation
 Ren, Y; Kardono, LB; Riswan, S; Chai, H; Farnsworth, NR; Soejarto, DD; Carcache de Blanco, EJ; Kinghorn, AD Cytotoxic and NF-kappaB inhibitory constituents of Artocarpus rigida. J Nat Prod 73:949-55 (2010) [PubMed]  Article 
Target
Name:
Nuclear factor NF-kappa-B p105 subunit
Synonyms:
NFKB1 | NFKB1_HUMAN | Nuclear factor NF-kappa-B (NF-kB) | Nuclear factor NF-kappa-B complex | Nuclear factor NF-kappa-B p105 subunit
Type:
Protein
Mol. Mass.:
105329.57
Organism:
Homo sapiens (Human)
Description:
P19838
Residue:
968
Sequence:
MAEDDPYLGRPEQMFHLDPSLTHTIFNPEVFQPQMALPTDGPYLQILEQPKQRGFRFRYVCEGPSHGGLPGASSEKNKKSYPQVKICNYVGPAKVIVQLVTNGKNIHLHAHSLVGKHCEDGICTVTAGPKDMVVGFANLGILHVTKKKVFETLEARMTEACIRGYNPGLLVHPDLAYLQAEGGGDRQLGDREKELIRQAALQQTKEMDLSVVRLMFTAFLPDSTGSFTRRLEPVVSDAIYDSKAPNASNLKIVRMDRTAGCVTGGEEIYLLCDKVQKDDIQIRFYEEEENGGVWEGFGDFSPTDVHRQFAIVFKTPKYKDINITKPASVFVQLRRKSDLETSEPKPFLYYPEIKDKEEVQRKRQKLMPNFSDSFGGGSGAGAGGGGMFGSGGGGGGTGSTGPGYSFPHYGFPTYGGITFHPGTTKSNAGMKHGTMDTESKKDPEGCDKSDDKNTVNLFGKVIETTEQDQEPSEATVGNGEVTLTYATGTKEESAGVQDNLFLEKAMQLAKRHANALFDYAVTGDVKMLLAVQRHLTAVQDENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHLAMMSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAGADPLVENFEPLYDLDDSWENAGEDEGVVPGTTPLDMATSWQVFDILNGKPYEPEFTSDDLLAQGDMKQLAEDVKLQLYKLLEIPDPDKNWATLAQKLGLGILNNAFRLSPAPSKTLMDNYEVSGGTVRELVEALRQMGYTEAIEVIQAASSPVKTTSQAHSLPLSPASTRQQIDELRDSDSVCDSGVETSFRKLSFTESLTSGASLLTLNKMPHDYGQEGPLEGKI
  
Inhibitor
Name:
BDBM50317858
Synonyms:
CHEMBL1095556 | cycloartobiloxanthone
Type:
Small organic molecule
Emp. Form.:
C25H22O7
Mol. Mass.:
434.438
SMILES:
CC1(C)Oc2c3[C@@H]1Cc1c(oc4c5C=CC(C)(C)Oc5cc(O)c4c1=O)-c3c(O)cc2O |r,c:14|
Structure:
Search PDB for entries with ligand similarity: