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Target
Histone deacetylase 8
Ligand
BDBM50317956
Substrate
n/a
Meas. Tech.
ChEMBL_630915 (CHEMBL1113907)
IC50
16±n/a nM
Citation
 Bressi, JC; de Jong, R; Wu, Y; Jennings, AJ; Brown, JW; O'Connell, S; Tari, LW; Skene, RJ; Vu, P; Navre, M; Cao, X; Gangloff, AR Benzimidazole and imidazole inhibitors of histone deacetylases: Synthesis and biological activity. Bioorg Med Chem Lett 20:3138-41 (2010) [PubMed]  Article 
Target
Name:
Histone deacetylase 8
Synonyms:
HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8
Type:
Enzyme
Mol. Mass.:
41749.60
Organism:
Homo sapiens (Human)
Description:
Q9BY41
Residue:
377
Sequence:
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
  
Inhibitor
Name:
BDBM50317956
Synonyms:
3-(3-(4-benzyl-5-methyl-1-phenethyl-1H-imidazol-2-yl)phenyl)-N-hydroxyacrylamide | CHEMBL1099048
Type:
Small organic molecule
Emp. Form.:
C28H27N3O2
Mol. Mass.:
437.5329
SMILES:
Cc1c(Cc2ccccc2)nc(-c2cccc(\C=C\C(=O)NO)c2)n1CCc1ccccc1
Structure:
Search PDB for entries with ligand similarity: