Reaction Details Report a problem with these data
Target
Histone deacetylase 1
Ligand
BDBM50317957
Substrate
n/a
Meas. Tech.
ChEMBL_630913 (CHEMBL1113905)
IC50
6.3±n/a nM
Citation
Bressi, JC; de Jong, R; Wu, Y; Jennings, AJ; Brown, JW; O'Connell, S; Tari, LW; Skene, RJ; Vu, P; Navre, M; Cao, X; Gangloff, AR Benzimidazole and imidazole inhibitors of histone deacetylases: Synthesis and biological activity. Bioorg Med Chem Lett 20:3138-41 (2010) [PubMed] Article
More Info.:
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
Inhibitor
Name:
BDBM50317957
Synonyms:
(R)-3-(3-(4-benzyl-5-methyl-1-(1-methylpiperidin-3-yl)-1H-imidazol-2-yl)phenyl)-N-hydroxyacrylamide | CHEMBL1099049
Type:
Small organic molecule
Emp. Form.:
C26H30N4O2
Mol. Mass.:
430.542
SMILES:
CN1CCC[C@H](C1)n1c(C)c(Cc2ccccc2)nc1-c1cccc(\C=C\C(=O)NO)c1 |r|