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Target
Histone deacetylase 1
Ligand
BDBM50317963
Substrate
n/a
Meas. Tech.
ChEMBL_630913 (CHEMBL1113905)
IC50
12±n/a nM
Citation
 Bressi, JC; de Jong, R; Wu, Y; Jennings, AJ; Brown, JW; O'Connell, S; Tari, LW; Skene, RJ; Vu, P; Navre, M; Cao, X; Gangloff, AR Benzimidazole and imidazole inhibitors of histone deacetylases: Synthesis and biological activity. Bioorg Med Chem Lett 20:3138-41 (2010) [PubMed]  Article 
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM50317963
Synonyms:
(R)-3-(3-(1-(1-ethylpiperidin-3-yl)-4,5-dimethyl-1H-imidazol-2-yl)phenyl)-N-hydroxyacrylamide | CHEMBL1096033
Type:
Small organic molecule
Emp. Form.:
C21H28N4O2
Mol. Mass.:
368.4726
SMILES:
CCN1CCC[C@H](C1)n1c(C)c(C)nc1-c1cccc(\C=C\C(=O)NO)c1 |r|
Structure:
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