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Target
Low molecular weight protein-tyrosine phosphatase A
Ligand
BDBM50193042
Substrate
n/a
Meas. Tech.
ChEMBL_639378 (CHEMBL1167758)
Ki
5400±n/a nM
Citation
 Mascarello, A; Chiaradia, LD; Vernal, J; Villarino, A; Guido, RV; Perizzolo, P; Poirier, V; Wong, D; Martins, PG; Nunes, RJ; Yunes, RA; Andricopulo, AD; Av-Gay, Y; Terenzi, H Inhibition of Mycobacterium tuberculosis tyrosine phosphatase PtpA by synthetic chalcones: kinetics, molecular modeling, toxicity and effect on growth. Bioorg Med Chem 18:3783-9 (2010) [PubMed]  Article 
Target
Name:
Low molecular weight protein-tyrosine phosphatase A
Synonyms:
PTPA_MYCTU | PTPase | Probable low molecular weight protein-tyrosine-phosphatase | Protein Tyrosine Phosphatase PTPA | mptpA | ptpA
Type:
Hydrolase
Mol. Mass.:
17891.84
Organism:
Mycobacterium tuberculosis
Description:
n/a
Residue:
163
Sequence:
MSDPLHVTFVCTGNICRSPMAEKMFAQQLRHRGLGDAVRVTSAGTGNWHVGSCADERAAGVLRAHGYPTDHRAAQVGTEHLAADLLVALDRNHARLLRQLGVEAARVRMLRSFDPRSGTHALDVEDPYYGDHSDFEEVFAVIESALPGLHDWVDERLARNGPS
  
Inhibitor
Name:
BDBM50193042
Synonyms:
(2E)-1-(2',5'-dimethoxyphenyl)-3-(2-naphthyl)-2-propen-1-one | 1-(2',5'-dimethoxyphenyl)-3-(2-naphthyl)-2-propen-1-one | 1-(2,5-dimethoxyphenyl)-3-(naphthalen-2-yl)prop-2-en-1-one | CHEMBL441861
Type:
Small organic molecule
Emp. Form.:
C21H18O3
Mol. Mass.:
318.3658
SMILES:
COc1ccc(OC)c(c1)C(=O)\C=C\c1ccc2ccccc2c1
Structure:
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