Reaction Details Report a problem with these data
Target
MO15-related protein kinase Pfmrk
Ligand
BDBM50321439
Substrate
n/a
Meas. Tech.
ChEMBL_640752 (CHEMBL1175693)
IC50
50200±n/a nM
Citation
 Caridha, D; Kathcart, AK; Jirage, D; Waters, NC Activity of substituted thiophene sulfonamides against malarial and mammalian cyclin dependent protein kinases. Bioorg Med Chem Lett 20:3863-7 (2010) [PubMed]  Article 
Target
Name:
MO15-related protein kinase Pfmrk
Synonyms:
Protein kinase Pfmrk
Type:
PROTEIN
Mol. Mass.:
37992.30
Organism:
Plasmodium falciparum
Description:
ChEMBL_640752
Residue:
324
Sequence:
MENNSTERYIFKPNFLGEGSYGKVYKAYDTILKKEVAIKKMKLNEISNYIDDCGINFVLLREIKIMKEIKHKNIMSALDLYCEKDYINLVMEIMDYDLSKIINRKIFLTDSQKKCILLQILNGLNVLHKYYFMHRDLSPANIFINKKGEVKLADFGLCTKYGYDMYSDKLFRDKYKKNLNLTSKVVTLWYRAPELLLGSNKYNSSIDMWSFGCIFAELLLQKALFPGENEIDQLGKIFFLLGTPNENNWPEALCLPLYTEFTKATKKDFKTYFKIDDDDCIDLLTSFLKLNAHERISAEDAMKHRYFFNDPLPCDISQLPFNDL
  
Inhibitor
Name:
BDBM50321439
Synonyms:
CHEMBL1172128 | N,N'-(2,4,6-trimethyl-1,3-phenylene)bis(4-bromobenzenesulfonamide)
Type:
Small organic molecule
Emp. Form.:
C21H20Br2N2O4S2
Mol. Mass.:
588.333
SMILES:
Cc1cc(C)c(NS(=O)(=O)c2ccc(Br)cc2)c(C)c1NS(=O)(=O)c1ccc(Br)cc1
Structure:
Search PDB for entries with ligand similarity: