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Target
Orexin receptor type 2
Ligand
BDBM50321512
Substrate
n/a
Meas. Tech.
ChEMBL_639602 (CHEMBL1175135)
Ki
2.9±n/a nM
Citation
 Coleman, PJ; Schreier, JD; Roecker, AJ; Mercer, SP; McGaughey, GB; Cox, CD; Hartman, GD; Harrell, CM; Reiss, DR; Doran, SM; Garson, SL; Anderson, WB; Tang, C; Prueksaritanont, T; Winrow, CJ; Renger, JJ Discovery of 3,9-diazabicyclo[4.2.1]nonanes as potent dual orexin receptor antagonists with sleep-promoting activity in the rat. Bioorg Med Chem Lett 20:4201-5 (2010) [PubMed]  Article 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM50321512
Synonyms:
((1R,5S)-3-(7-fluoroquinazolin-2-yl)-3,6-diazabicyclo[3.2.2]nonan-6-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone | CHEMBL1172519
Type:
Small organic molecule
Emp. Form.:
C25H24FN7O
Mol. Mass.:
457.5028
SMILES:
Cc1ccc(c(c1)C(=O)N1C[C@H]2CC[C@@H]1CN(C2)c1ncc2ccc(F)cc2n1)-n1nccn1 |r,THB:7:9:15.16.17:13.12|
Structure:
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