Reaction Details Report a problem with these data
Target
Cysteinyl leukotriene receptor 1
Ligand
BDBM50069356
Substrate
n/a
Meas. Tech.
ChEMBL_647615 (CHEMBL1219966)
IC50
0.19±n/a nM
Citation
 Dong, X; Wang, L; Huang, X; Liu, T; Wei, E; Du, L; Yang, B; Hu, Y Pharmacophore identification, synthesis, and biological evaluation of carboxylated chalcone derivatives as CysLT1 antagonists. Bioorg Med Chem 18:5519-27 (2010) [PubMed]  Article 
Target
Name:
Cysteinyl leukotriene receptor 1
Synonyms:
Leukotriene Cysteinyl 1 | Cysteinyl leukotriene receptor | HMTMF81 | LTD4 receptor | Cysteinyl leukotriene D4 receptor | HG55 | CLTR1_HUMAN | CYSLTR1 | CYSLT1 | Cysteinyl leukotriene receptor 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
38565.16
Organism:
Human
Description:
Leukotriene Cysteinyl 1 CYSLTR1 HUMAN::Q9Y271
Residue:
337
Sequence:
MDETGNLTVSSATCHDTIDDFRNQVYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCFEPPQDNQTKNHVLVLHYVSLFVGFIIPFVIIIVCYTMIILTLLKKSMKKNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTIHLHFLHNETKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRLSTFRKHSLSSVTYVPRKKASLPEKGEEICKV
  
Inhibitor
Name:
BDBM50069356
Synonyms:
[1-((R)-3-[2-(1-Hydroxy-1-methyl-ethyl)-phenyl]-1-{3-[(E)-2-(5,6,7,8-tetrahydro-quinolin-2-yl)-vinyl]-phenyl}-propylsulfanylmethyl)-cyclopropyl]-acetic acid | (R)-2-(1-((3-(2-(2-hydroxypropan-2-yl)phenyl)-1-(3-(2-(5,6,7,8-tetrahydroquinolin-2-yl)vinyl)phenyl)propylthio)methyl)cyclopropyl)acetic acid | CHEMBL344180
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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