Reaction Details Report a problem with these data
Target
Cysteinyl leukotriene receptor 1
Ligand
BDBM50084785
Substrate
n/a
Meas. Tech.
ChEMBL_647615 (CHEMBL1219966)
IC50
30±n/a nM
Citation
 Dong, X; Wang, L; Huang, X; Liu, T; Wei, E; Du, L; Yang, B; Hu, Y Pharmacophore identification, synthesis, and biological evaluation of carboxylated chalcone derivatives as CysLT1 antagonists. Bioorg Med Chem 18:5519-27 (2010) [PubMed]  Article 
Target
Name:
Cysteinyl leukotriene receptor 1
Synonyms:
CLTR1_HUMAN | CYSLT1 | CYSLTR1 | Cysteinyl leukotriene D4 receptor | Cysteinyl leukotriene receptor | Cysteinyl leukotriene receptor 1 | HG55 | HMTMF81 | LTD4 receptor | Leukotriene Cysteinyl 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
38565.16
Organism:
Homo sapiens (Human)
Description:
Leukotriene Cysteinyl 1 CYSLTR1 HUMAN::Q9Y271
Residue:
337
Sequence:
MDETGNLTVSSATCHDTIDDFRNQVYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCFEPPQDNQTKNHVLVLHYVSLFVGFIIPFVIIIVCYTMIILTLLKKSMKKNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTIHLHFLHNETKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRLSTFRKHSLSSVTYVPRKKASLPEKGEEICKV
  
Inhibitor
Name:
BDBM50084785
Synonyms:
(4-{2-[6-(Quinolin-2-ylmethoxy)-naphthalen-2-yl]-propionylamino}-phenyl)-acetic acid | 2-(4-(2-(6-(quinolin-2-ylmethoxy)naphthalen-2-yl)propanamido)phenyl)acetic acid | CHEMBL129866
Type:
Small organic molecule
Emp. Form.:
C31H26N2O4
Mol. Mass.:
490.5491
SMILES:
CC(C(=O)Nc1ccc(CC(O)=O)cc1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1
Structure:
Search PDB for entries with ligand similarity: