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Target
Sialidase-3
Ligand
BDBM50331688
Substrate
n/a
Meas. Tech.
ChEMBL_687674 (CHEMBL1291058)
IC50
>500000±n/a nM
Citation
 Zou, Y; Albohy, A; Sandbhor, M; Cairo, CW Inhibition of human neuraminidase 3 (NEU3) by C9-triazole derivatives of 2,3-didehydro-N-acetyl-neuraminic acid. Bioorg Med Chem Lett 20:7529-33 (2010) [PubMed]  Article 
Target
Name:
Sialidase-3
Synonyms:
NEU3 | NEUR3_HUMAN | Sialidase 3 | Sialidase-3
Type:
PROTEIN
Mol. Mass.:
48257.99
Organism:
Homo sapiens (Human)
Description:
ChEMBL_461856
Residue:
428
Sequence:
MEEVTTCSFNSPLFRQEDDRGITYRIPALLYIPPTHTFLAFAEKRSTRRDEDALHLVLRRGLRIGQLVQWGPLKPLMEATLPGHRTMNPCPVWEQKSGCVFLFFICVRGHVTERQQIVSGRNAARLCFIYSQDAGCSWSEVRDLTEEVIGSELKHWATFAVGPGHGIQLQSGRLVIPAYTYYIPSWFFCFQLPCKTRPHSLMIYSDDLGVTWHHGRLIRPMVTVECEVAEVTGRAGHPVLYCSARTPNRCRAEALSTDHGEGFQRLALSRQLCEPPHGCQGSVVSFRPLEIPHRCQDSSSKDAPTIQQSSPGSSLRLEEEAGTPSESWLLYSHPTSRKQRVDLGIYLNQTPLEAACWSRPWILHCGPCGYSDLAALEEEGLFGCLFECGTKQECEQIAFRLFTHREILSHLQGDCTSPGRNPSQFKSN
  
Inhibitor
Name:
BDBM50331688
Synonyms:
(2R,3R,4S)-4-hydroxy-3-(2-(4-(hydroxymethyl)-1H-1,2,3-triazol-1-yl)acetamido)-2-((1R,2R)-1,2,3-trihydroxypropyl)-3,4-dihydro-2H-pyran-6-carboxylate | CHEMBL1290182
Type:
Small organic molecule
Emp. Form.:
C14H20N4O9
Mol. Mass.:
388.33
SMILES:
OC[C@@H](O)[C@@H](O)[C@@H]1OC(=C[C@H](O)[C@H]1NC(=O)Cn1cc(CO)nn1)C(O)=O |r,c:8|
Structure:
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