Reaction Details Report a problem with these data
Target
Guanine deaminase
Ligand
BDBM50378883
Substrate
n/a
Meas. Tech.
ChEMBL_698686 (CHEMBL1648250)
Ki
16700±n/a nM
Citation
 Chakraborty, S; Shah, NH; Fishbein, JC; Hosmane, RS A novel transition state analog inhibitor of guanase based on azepinomycin ring structure: Synthesis and biochemical assessment of enzyme inhibition. Bioorg Med Chem Lett 21:756-9 (2011) [PubMed]  Article 
Target
Name:
Guanine deaminase
Synonyms:
GAH | GDA | GUAD_HUMAN | Guanase | Guanine aminase | Guanine aminohydrolase | KIAA1258 | p51-nedasin
Type:
PROTEIN
Mol. Mass.:
50993.86
Organism:
Homo sapiens (Human)
Description:
ChEMBL_885179
Residue:
454
Sequence:
MCAAQMPPLAHIFRGTFVHSTWTCPMEVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTLKNGTTTACYFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEYKETTEESIKETERFVSEMLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIAHCPNSNLSLSSGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKASDSPIDLFYGDFFGDISEAVIQKFLYLGDDRNIEEVYVGGKQVVPFSSSV
  
Inhibitor
Name:
BDBM50378883
Synonyms:
CHEMBL1645489
Type:
Small organic molecule
Emp. Form.:
C22H21N5O5
Mol. Mass.:
435.4326
SMILES:
OCC1(NC(=O)OCc2ccccc2)NC(=O)c2ncn(Cc3ccccc3)c2NC1=O
Structure:
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