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Target
Sodium-dependent dopamine transporter
Ligand
BDBM50156055
Substrate
n/a
Meas. Tech.
ChEMBL_718910 (CHEMBL1681404)
Ki
2520±n/a nM
Citation
 Cao, J; Prisinzano, TE; Okunola, OM; Kopajtic, T; Shook, M; Katz, JL; Newman, AH Structure-Activity Relationships at the Monoamine Transporters for a Novel Series of Modafinil (2-[(diphenylmethyl)sulfinyl]acetamide) Analogues. ACS Med Chem Lett 2:48-52 (2011) [PubMed]  Article 
Target
Name:
Sodium-dependent dopamine transporter
Synonyms:
DA transporter | Monoamine transporters; Norepininephrine & dopamine | SC6A3_RAT | Slc6a3 | Sodium-dependent dopamine transporter | Sodium-dependent dopamine transporter (DAT)
Type:
Multi-pass membrane protein
Mol. Mass.:
68749.45
Organism:
Rattus norvegicus (rat)
Description:
P23977
Residue:
619
Sequence:
MSKSKCSVGPMSSVVAPAKESNAVGPREVELILVKEQNGVQLTNSTLINPPQTPVEAQERETWSKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWKICPVLKGVGFTVILISFYVGFFYNVIIAWALHYFFSSFTMDLPWIHCNNTWNSPNCSDAHASNSSDGLGLNDTFGTTPAAEYFERGVLHLHQSRGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAMDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIITTSINSLTSFSSGFVVFSFLGYMAQKHNVPIRDVATDGPGLIFIIYPEAIATLPLSSAWAAVFFLMLLTLGIDSAMGGMESVITGLVDEFQLLHRHRELFTLGIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVQQFSDDIKQMTGQRPNLYWRLCWKLVSPCFLLYVVVVSIVTFRPPHYGAYIFPDWANALGWIIATSSMAMVPIYATYKFCSLPGSFREKLAYAITPEKDHQLVDRGEVRQFTLRHWLLL
  
Inhibitor
Name:
BDBM50156055
Synonyms:
2-(Diphenyl-methanesulfinyl)-acetamide | 2-(benzhydrylsulfinyl)acetamide | 2-[(diphenylmethyl)sulfinyl]acetamide | Ambrisentan | CEP-1538 | CHEMBL1373 | CRL-40476 | MODAFINIL | Provigil | US10913711, Compound (+-)-modafinilb | US11555013, Compound (+-)-modafinilb | US9862679, Compound (+-)-modafinil
Type:
Small organic molecule
Emp. Form.:
C15H15NO2S
Mol. Mass.:
273.35
SMILES:
NC(=O)CS(=O)C(c1ccccc1)c1ccccc1
Structure:
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