Reaction Details Report a problem with these data
Target
Steroid 17-alpha-hydroxylase/17,20 lyase
Ligand
BDBM50338366
Substrate
n/a
Meas. Tech.
ChEMBL_728149 (CHEMBL1687150)
IC50
21±n/a nM
Citation
 Kaku, T; Matsunaga, N; Ojida, A; Tanaka, T; Hara, T; Yamaoka, M; Kusaka, M; Tasaka, A 17,20-lyase inhibitors. Part 4: design, synthesis and structure-activity relationships of naphthylmethylimidazole derivatives as novel 17,20-lyase inhibitors. Bioorg Med Chem 19:1751-70 (2011) [PubMed]  Article 
Target
Name:
Steroid 17-alpha-hydroxylase/17,20 lyase
Synonyms:
CP17A_RAT | Cyp17 | Cyp17a1 | Cytochrome P450 17,20 lyase | Cytochrome P450 17A1 | Cytochrome P450-C17 | Steroid 17-alpha-hydroxylase/17,20 lyase
Type:
Enzyme
Mol. Mass.:
57255.68
Organism:
Rattus norvegicus (Rat)
Description:
P11715
Residue:
507
Sequence:
MWELVGLLLLILAYFFWVKSKTPGAKLPRSLPSLPLVGSLPFLPRRGHMHVNFFKLQEKYGPIYSLRLGTTTTVIIGHYQLAREVLIKKGKEFSGRPQMVTQSLLSDQGKGVAFADAGSSWHLHRKLVFSTFSLFKDGQKLEKLICQEAKSLCDMMLAHDKESIDLSTPIFMSVTNIICAICFNISYEKNDPKLTAIKTFTEGIVDATGDRNLVDIFPWLTIFPNKGLEVIKGYAKVRNEVLTGIFEKCREKFDSQSISSLTDILIQAKMNSDNNNSCEGRDPDVFSDRHILATVGDIFGAGIETTTTVLKWILAFLVHNPEVKKKIQKEIDQYVGFSRTPTFNDRSHLLMLEATIREVLRIRPVAPMLIPHKANVDSSIGEFTVPKDTHVVVNLWALHHDENEWDQPDQFMPERFLDPTGSHLITPTQSYLPFGAGPRSCIGEALARQELFVFTALLLQRFDLDVSDDKQLPRLEGDPKVVFLIDPFKVKITVRQAWMDAQAEVST
  
Inhibitor
Name:
BDBM50338366
Synonyms:
(S)-1-(1H-imidazol-4-yl)-1-(6-methoxynaphthalen-2-yl)-2-methylpropan-1-ol | CHEMBL1682887
Type:
Small organic molecule
Emp. Form.:
C18H20N2O2
Mol. Mass.:
296.3636
SMILES:
COc1ccc2cc(ccc2c1)[C@@](O)(C(C)C)c1cnc[nH]1 |r|
Structure:
Search PDB for entries with ligand similarity: