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Target
Steroid 11-beta-monooxygenase
Ligand
BDBM50338356
Substrate
n/a
Meas. Tech.
ChEMBL_728153 (CHEMBL1687154)
IC50
13.0±n/a nM
Citation
 Kaku, T; Matsunaga, N; Ojida, A; Tanaka, T; Hara, T; Yamaoka, M; Kusaka, M; Tasaka, A 17,20-lyase inhibitors. Part 4: design, synthesis and structure-activity relationships of naphthylmethylimidazole derivatives as novel 17,20-lyase inhibitors. Bioorg Med Chem 19:1751-70 (2011) [PubMed]  Article 
Target
Name:
Steroid 11-beta-monooxygenase
Synonyms:
Cytochrome P450c11B3
Type:
PROTEIN
Mol. Mass.:
57146.22
Organism:
Rattus norvegicus
Description:
ChEMBL_728153
Residue:
498
Sequence:
MALRVTADVWARPWQCLHRTRALGSTATQAPKTLKPFEAIPQYSRNKWLKMIQILREQGQENLHLEMHQAFQELGPIFRHSAGGAQIVSVMLPEDAEKLHQVESILPRRMTLESWVAHRELRGLRRGVFLLNGADWRFNRLQLNPNMLSPKAVQSFVPFVDVVARDFVENLKKRMLENVHGSMSMDIQSNVFNYTMEASHFVISGERLGLTGHDLNPESLKFIHALHSMFKSTTQLMFLPKNLTRWTSTQVWKGHFESWDIISEYVTNVSRNVYRELAEGRQQSWSVISEMVAQSTLSMDAIHANSMELIAGSVDTTAISLVMTLFELARNPDVQQALRQESLAAEASIAANPQKAMSDLPLLRAALKETLRLYPIGSSLERIVDSDLVLQNYHVPAGTLVIIYLYSMGRNPAVFPRPERYMPQRWLERKRSFQHLAFGFGVRQCLGRRLAEVEVLLLLHHMLKIFQVETLRQEDVQMAYRFVLMPNPRLVLTIRPVS
  
Inhibitor
Name:
BDBM50338356
Synonyms:
(+)-7-[1-Hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-1,2-dihydro-3H-benzo[e]isoindol-3-one | (-)-7-[1-Hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-1,2-dihydro-3H-benzo[e]isoindol-3-one | CHEMBL1682900 | rac-7-[1-Hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-1,2-dihydro-3H-benzo[e]isoindol-3-one
Type:
Small organic molecule
Emp. Form.:
C19H19N3O2
Mol. Mass.:
321.3731
SMILES:
CC(C)C(O)(c1cnc[nH]1)c1ccc2c3CNC(=O)c3ccc2c1
Structure:
Search PDB for entries with ligand similarity: