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Target
Mannosyl-oligosaccharide alpha-1,2-mannosidase IA
Ligand
BDBM50339275
Substrate
n/a
Meas. Tech.
ChEMBL_736246 (CHEMBL1693390)
IC50
2500000±n/a nM
Citation
 Poláková, M; Šeták, S; Lattová, E; Petruš, L; Mucha, J; Tvaroška, I; Kóna, J a-D-mannose derivatives as models designed for selective inhibition of Golgia-mannosidase II. Eur J Med Chem 46:944-52 (2011) [PubMed]  Article 
Target
Name:
Mannosyl-oligosaccharide alpha-1,2-mannosidase IA
Synonyms:
MA1A1_DROME | Man(9)-alpha-mannosidase | Mannosidase-1 | Mannosyl-oligosaccharide alpha-1,2-mannosidase isoform B | alpha-Man-Ia | alpha-man-1 | mas-1
Type:
PROTEIN
Mol. Mass.:
74961.37
Organism:
Drosophila melanogaster
Description:
ChEMBL_103952
Residue:
667
Sequence:
MYRISPIGRKSNFHSREKCLIGLVLVTLCFLCFGGIFLLPDNFGSDRVLRVYKHFRKAGPEIFIPAPPLAAHAPHRSEDPHFIGDRQRLEQKIRAELGDMLDEPPAAGGGEPGQFQVLAQQAQAPAPVAALADQPLDQDEGHAAIPVLAAPVQGDNAASQASSHPQSSAQQHNQQQPQLPLGGGGNDQAPDTLDATLEERRQKVKEMMEHAWHNYKLYAWGKNELRPLSQRPHSASIFGSYDLGATIVDGLDTLYIMGLEKEYREGRDWIERKFSLDNISAELSVFETNIRFVGGMLTLYAFTGDPLYKEKAQHVADKLLPAFQTPTGIPYALVNTKTGVAKNYGWASGGSSILSEFGTLHLEFAYLSDITGNPLYRERVQTIRQVLKEIEKPKGLYPNFLNPKTGKWGQLHMSLGALGDSYYEYLLKAWLQSGQTDEEAREMFDEAMLAILDKMVRTSPGGLTYVSDLKFDRLEHKMDHLACFSGGLFALGAATRQNDYTDKYMEVGKGITNTCHESYIRAPTQLGPEAFRFSEAVEARALRSQEKYYILRPETFESYFVLWRLTHDQKYRDWGWEAVLALEKHCRTAHGYCGLRNVYQQEPQKDDVQQSFFLAETLKYLYLLFSDDSVLPLDEWVFNTEAHPLPIKGANAYYRQAPVTLPVSNAS
  
Inhibitor
Name:
BDBM50339275
Synonyms:
(2R,3S,4S,5S,6R)-2-(hexylsulfonyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol | CHEMBL1689641
Type:
Small organic molecule
Emp. Form.:
C12H24O7S
Mol. Mass.:
312.38
SMILES:
CCCCCCS(=O)(=O)[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]1O |r|
Structure:
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