Reaction Details Report a problem with these data
Target
Cannabinoid receptor 2
Ligand
BDBM50342047
Substrate
n/a
Meas. Tech.
ChEMBL_743740 (CHEMBL1767554)
Ki
2370±n/a nM
Citation
 Donohue, SR; Dannals, RF; Halldin, C; Pike, VW N-(4-cyanotetrahydro-2H-pyran-4-yl) and N-(1-cyanocyclohexyl) derivatives of 1,5-diarylpyrazole-3-carboxamides showing high affinity for 18 kDa translocator protein and/or cannabinoid receptors. J Med Chem 54:2961-70 (2011) [PubMed]  Article 
Target
Name:
Cannabinoid receptor 2
Synonyms:
CANNABINOID CB2 | CB-2 | CB2 | CB2A | CB2B | CNR2 | CNR2_HUMAN | CX5 | Cannabinoid CB2 receptor | Cannabinoid receptor 2 (CB2) | Cannabinoid receptor 2 (CB2R) | hCB2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
39690.94
Organism:
Homo sapiens (Human)
Description:
P34972
Residue:
360
Sequence:
MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCSELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLDVRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC
  
Inhibitor
Name:
BDBM50342047
Synonyms:
4-Cyano-N-(4-cyanotetrahydro-2H-pyran-4-yl)-1-(2-iodophenyl)-5-(4-methoxyphenyl)-1H-pyrazole-3-carboxamide | CHEMBL1765818
Type:
Small organic molecule
Emp. Form.:
C24H20IN5O3
Mol. Mass.:
553.3518
SMILES:
COc1ccc(cc1)-c1c(C#N)c(nn1-c1ccccc1I)C(=O)NC1(CCOCC1)C#N
Structure:
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