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Target
Translocator protein
Ligand
BDBM50342044
Substrate
n/a
Meas. Tech.
ChEMBL_743741 (CHEMBL1767555)
Ki
155±n/a nM
Citation
 Donohue, SR; Dannals, RF; Halldin, C; Pike, VW N-(4-cyanotetrahydro-2H-pyran-4-yl) and N-(1-cyanocyclohexyl) derivatives of 1,5-diarylpyrazole-3-carboxamides showing high affinity for 18 kDa translocator protein and/or cannabinoid receptors. J Med Chem 54:2961-70 (2011) [PubMed]  Article 
Target
Name:
Translocator protein
Synonyms:
Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo
Type:
Mitochondrion membrane protein
Mol. Mass.:
18945.84
Organism:
Rattus norvegicus (rat)
Description:
Competitive binding experiments were performed on rat kidney mitochondrial membranes.
Residue:
169
Sequence:
MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAMGYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVATATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
  
Inhibitor
Name:
BDBM50342044
Synonyms:
4-Bromo-1-(3-bromophenyl)-N-(4-cyanotetrahydro-2H-pyran-4-yl)-5-(4-methoxyphenyl)-1H-pyrazole-3-carboxamide | CHEMBL1765819
Type:
Small organic molecule
Emp. Form.:
C23H20Br2N4O3
Mol. Mass.:
560.238
SMILES:
COc1ccc(cc1)-c1c(Br)c(nn1-c1cccc(Br)c1)C(=O)NC1(CCOCC1)C#N
Structure:
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