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Target
Translocator protein
Ligand
BDBM50342048
Substrate
n/a
Meas. Tech.
ChEMBL_743741 (CHEMBL1767555)
Ki
394±n/a nM
Citation
 Donohue, SR; Dannals, RF; Halldin, C; Pike, VW N-(4-cyanotetrahydro-2H-pyran-4-yl) and N-(1-cyanocyclohexyl) derivatives of 1,5-diarylpyrazole-3-carboxamides showing high affinity for 18 kDa translocator protein and/or cannabinoid receptors. J Med Chem 54:2961-70 (2011) [PubMed]  Article 
Target
Name:
Translocator protein
Synonyms:
Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo
Type:
Mitochondrion membrane protein
Mol. Mass.:
18945.84
Organism:
Rattus norvegicus (rat)
Description:
Competitive binding experiments were performed on rat kidney mitochondrial membranes.
Residue:
169
Sequence:
MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAMGYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVATATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
  
Inhibitor
Name:
BDBM50342048
Synonyms:
CHEMBL1765673 | N-(4-Cyanotetrahydro-2H-pyran-4-yl)-1-(2-fluorophenyl)-4-methyl-5-phenyl-1H-pyrazole-3-carboxamide
Type:
Small organic molecule
Emp. Form.:
C23H21FN4O2
Mol. Mass.:
404.4368
SMILES:
Cc1c(nn(c1-c1ccccc1)-c1ccccc1F)C(=O)NC1(CCOCC1)C#N
Structure:
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