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Target
cAMP-dependent protein kinase catalytic subunit beta
Ligand
BDBM50342212
Substrate
n/a
Meas. Tech.
ChEMBL_743045 (CHEMBL1768516)
IC50
23550±n/a nM
Citation
 Djung, JF; Mears, RJ; Montalbetti, CA; Coulter, TS; Golebiowski, A; Carr, AN; Barker, O; Greis, KD; Zhou, S; Dolan, E; Davis, GF The synthesis and evaluation of indolylureas as PKCa inhibitors. Bioorg Med Chem 19:2742-50 (2011) [PubMed]  Article 
Target
Name:
cAMP-dependent protein kinase catalytic subunit beta
Synonyms:
KAPCB_HUMAN | PKA C-beta | PKAC-beta | PRKACB | cAMP-dependent protein kinase (PKA) | cAMP-dependent protein kinase beta-1 catalytic subunit | cAMP-dependent protein kinase catalytic subunit beta
Type:
PROTEIN
Mol. Mass.:
40631.25
Organism:
Homo sapiens (Human)
Description:
ChEMBL_586348
Residue:
351
Sequence:
MGNAATAKKGSEVESVKEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFDDYEEEDIRVSITEKCAKEFGEF
  
Inhibitor
Name:
BDBM50342212
Synonyms:
1-[1-(3-Dimethylaminopropyl)-1H-indol-3-yl]-3-(4-phenylpyrimidin-2-yl)urea | CHEMBL1766422
Type:
Small organic molecule
Emp. Form.:
C24H26N6O
Mol. Mass.:
414.5028
SMILES:
CN(C)CCCn1cc(NC(=O)Nc2nccc(n2)-c2ccccc2)c2ccccc12
Structure:
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