Reaction Details Report a problem with these data
Target
Protein tyrosine phosphatase type IVA 1
Ligand
BDBM50343147
Substrate
n/a
Meas. Tech.
ChEMBL_745332 (CHEMBL1775407)
IC50
>50000±n/a nM
Citation
 Chen, L; Zhou, B; Zhang, S; Wu, L; Wang, Y; Franzblau, SG; Zhang, ZY Identification and characterization of novel inhibitors of mPTPB, an essential virulent phosphatase from Mycobacterium tuberculosis. ACS Med Chem Lett 1:355-359 (2010) [PubMed]  Article 
Target
Name:
Protein tyrosine phosphatase type IVA 1
Synonyms:
PRL1 | PTP4A1 | PTPCAAX1 | TP4A1_HUMAN
Type:
PROTEIN
Mol. Mass.:
19823.94
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1461024
Residue:
173
Sequence:
MARMNRPAPVEVTYKNMRFLITHNPTNATLNKFIEELKKYGVTTIVRVCEATYDTTLVEKEGIHVLDWPFDDGAPPSNQIVDDWLSLVKIKFREEPGCCIAVHCVAGLGRAPVLVALALIEGGMKYEDAVQFIRQKRRGAFNSKQLLYLEKYRPKMRLRFKDSNGHRNNCCIQ
  
Inhibitor
Name:
BDBM50343147
Synonyms:
CHEMBL1773180 | N1-(furan-2-ylmethyl)-N2-(1-(4-(4-methoxyphenyl)piperazin-1-yl)-1-(thiophen-2-yl)propan-2-yl)oxalamide
Type:
Small organic molecule
Emp. Form.:
C25H30N4O4S
Mol. Mass.:
482.595
SMILES:
COc1ccc(cc1)N1CCN(CC1)C(C(C)NC(=O)C(=O)NCc1ccco1)c1cccs1
Structure:
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