Reaction Details Report a problem with these data
Target
Protein tyrosine phosphatase type IVA 1
Ligand
BDBM50343148
Substrate
n/a
Meas. Tech.
ChEMBL_745332 (CHEMBL1775407)
IC50
>50000±n/a nM
Citation
 Chen, L; Zhou, B; Zhang, S; Wu, L; Wang, Y; Franzblau, SG; Zhang, ZY Identification and characterization of novel inhibitors of mPTPB, an essential virulent phosphatase from Mycobacterium tuberculosis. ACS Med Chem Lett 1:355-359 (2010) [PubMed]  Article 
Target
Name:
Protein tyrosine phosphatase type IVA 1
Synonyms:
PRL1 | PTP4A1 | PTPCAAX1 | TP4A1_HUMAN
Type:
PROTEIN
Mol. Mass.:
19823.94
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1461024
Residue:
173
Sequence:
MARMNRPAPVEVTYKNMRFLITHNPTNATLNKFIEELKKYGVTTIVRVCEATYDTTLVEKEGIHVLDWPFDDGAPPSNQIVDDWLSLVKIKFREEPGCCIAVHCVAGLGRAPVLVALALIEGGMKYEDAVQFIRQKRRGAFNSKQLLYLEKYRPKMRLRFKDSNGHRNNCCIQ
  
Inhibitor
Name:
BDBM50343148
Synonyms:
CHEMBL1773181 | N1-(1-(4-(4-fluorophenyl)piperazin-1-yl)-1-(thiophen-2-yl)propan-2-yl)-N2-(pyridin-3-ylmethyl)oxalamide
Type:
Small organic molecule
Emp. Form.:
C25H28FN5O2S
Mol. Mass.:
481.586
SMILES:
CC(NC(=O)C(=O)NCc1cccnc1)C(N1CCN(CC1)c1ccc(F)cc1)c1cccs1
Structure:
Search PDB for entries with ligand similarity: