Reaction Details Report a problem with these data
Target
Dual specificity protein phosphatase CDC14A
Ligand
BDBM50343147
Substrate
n/a
Meas. Tech.
ChEMBL_745330 (CHEMBL1775405)
IC50
>50000±n/a nM
Citation
 Chen, L; Zhou, B; Zhang, S; Wu, L; Wang, Y; Franzblau, SG; Zhang, ZY Identification and characterization of novel inhibitors of mPTPB, an essential virulent phosphatase from Mycobacterium tuberculosis. ACS Med Chem Lett 1:355-359 (2010) [PubMed]  Article 
Target
Name:
Dual specificity protein phosphatase CDC14A
Synonyms:
3.1.3.16 | 3.1.3.48 | CC14A_HUMAN | CDC14 cell division cycle 14 homolog A | CDC14A
Type:
n/a
Mol. Mass.:
66598.40
Organism:
Homo sapiens (Human)
Description:
Q9UNH5
Residue:
594
Sequence:
MAAESGELIGACEFMKDRLYFATLRNRPKSTVNTHYFSIDEELVYENFYADFGPLNLAMVYRYCCKLNKKLKSYSLSRKKIVHYTCFDQRKRANAAFLIGAYAVIYLKKTPEEAYRALLSGSNPPYLPFRDASFGNCTYNLTILDCLQGIRKGLQHGFFDFETFDVDEYEHYERVENGDFNWIVPGKFLAFSGPHPKSKIENGYPLHAPEAYFPYFKKHNVTAVVRLNKKIYEAKRFTDAGFEHYDLFFIDGSTPSDNIVRRFLNICENTEGAIAVHCKAGLGRTGTLIACYVMKHYRFTHAEIIAWIRICRPGSIIGPQQHFLEEKQASLWVQGDIFRSKLKNRPSSEGSINKILSGLDDMSIGGNLSKTQNMERFGEDNLEDDDVEMKNGITQGDKLRALKSQRQPRTSPSCAFRSDDTKGHPRAVSQPFRLSSSLQGSAVTLKTSKMALSPSATAKRINRTSLSSGATVRSFSINSRLASSLGNLNAATDDPENKKTSSSSKAGFTASPFTNLLNGSSQPTTRNYPELNNNQYNRSSNSNGGNLNSPPGPHSAKTEEHTTILRPSYTGLSSSSARFLSRSIPSLQSEYVHY
  
Inhibitor
Name:
BDBM50343147
Synonyms:
CHEMBL1773180 | N1-(furan-2-ylmethyl)-N2-(1-(4-(4-methoxyphenyl)piperazin-1-yl)-1-(thiophen-2-yl)propan-2-yl)oxalamide
Type:
Small organic molecule
Emp. Form.:
C25H30N4O4S
Mol. Mass.:
482.595
SMILES:
COc1ccc(cc1)N1CCN(CC1)C(C(C)NC(=O)C(=O)NCc1ccco1)c1cccs1
Structure:
Search PDB for entries with ligand similarity: