Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50353283
Substrate
n/a
Meas. Tech.
ChEMBL_768720 (CHEMBL1831503)
Ki
25.8±n/a nM
Citation
 Abate, C; Ferorelli, S; Contino, M; Marottoli, R; Colabufo, NA; Perrone, R; Berardi, F Arylamides hybrids of two high-affinitys2 receptor ligands as tools for the development of PET radiotracers. Eur J Med Chem 46:4733-41 (2011) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:
Protein
Mol. Mass.:
25307.17
Organism:
Cavia porcellus (Guinea pig)
Description:
Q60492
Residue:
223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSKLIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50353283
Synonyms:
CHEMBL1830687
Type:
Small organic molecule
Emp. Form.:
C22H34BrN3O3
Mol. Mass.:
468.428
SMILES:
COc1cc(Br)cc(C(=O)NCCCN2CCN(CC2)C2CCCCC2)c1OC
Structure:
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