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Target
Translocator protein
Ligand
BDBM50353507
Substrate
n/a
Meas. Tech.
ChEMBL_769241 (CHEMBL1833078)
Ki
>10000±n/a nM
Citation
 Cosimelli, B; Simorini, F; Taliani, S; La Motta, C; Da Settimo, F; Severi, E; Greco, G; Novellino, E; Costa, B; Da Pozzo, E; Bendinelli, S; Martini, C Tertiary amides with a five-membered heteroaromatic ring as new probes for the translocator protein. Eur J Med Chem 46:4506-20 (2011) [PubMed]  Article 
Target
Name:
Translocator protein
Synonyms:
Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo
Type:
Mitochondrion membrane protein
Mol. Mass.:
18945.84
Organism:
Rattus norvegicus (rat)
Description:
Competitive binding experiments were performed on rat kidney mitochondrial membranes.
Residue:
169
Sequence:
MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAMGYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVATATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
  
Inhibitor
Name:
BDBM50353507
Synonyms:
CHEMBL1830741
Type:
Small organic molecule
Emp. Form.:
C22H31ClN2O2
Mol. Mass.:
390.947
SMILES:
CCCCCCN(CCCCCC)C(=O)c1cc(on1)-c1ccc(Cl)cc1
Structure:
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