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Target
5-hydroxytryptamine receptor 2A
Ligand
BDBM50354105
Substrate
n/a
Meas. Tech.
ChEMBL_770978 (CHEMBL1838217)
Ki
700±n/a nM
Citation
 Slowinski, T; Stefanowicz, J; Dawidowski, M; Kleps, J; Czuczwar, S; Andres-Mach, M; Luszczki, JJ; Nowak, G; Stachowicz, K; Szewczyk, B; Slawinska, A; Mazurek, AP; Mazurek, A; Plucinski, F; Wolska, I; Herold, F Synthesis and biological investigation of potential atypical antipsychotics with a tropane core. Part 1. Eur J Med Chem 46:4474-88 (2011) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 2A
Synonyms:
5-HT-2A | 5-HT2 | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | 5HT2A_RAT | Htr2 | Htr2a | Serotonin Receptor 2A
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
52852.05
Organism:
Rattus norvegicus (rat)
Description:
Rat cortex membranes 5-HT2A receptors.
Residue:
471
Sequence:
MEILCEDNISLSSIPNSLMQLGDGPRLYHNDFNSRDANTSEASNWTIDAENRTNLSCEGYLPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAIWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVAFFIPLTIMVITYFLTIKSLQKEATLCVSDLSTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYAGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNENVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILVNTIPALAYKSSQLQVGQKKNSQEDAEQTVDDCSMVTLGKQQSEENCTDNIETVNEKVSCV
  
Inhibitor
Name:
BDBM50354105
Synonyms:
CHEMBL1836110
Type:
Small organic molecule
Emp. Form.:
C22H27N3O3
Mol. Mass.:
381.4681
SMILES:
COc1cccc(C(=O)NC2C[C@H]3CC[C@H](C2)N3Cc2ccncc2)c1OC |r,TLB:9:10:17:13.14|
Structure:
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