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Target
MAP kinase-interacting serine/threonine-protein kinase 2
Ligand
BDBM50379077
Substrate
n/a
Meas. Tech.
ChEMBL_809673 (CHEMBL2015892)
IC50
>10000±n/a nM
Citation
 Xu, J; Chen, A; Go, ML; Nacro, K; Liu, B; Chai, CL Exploring aigialomycin d and its analogues as protein kinase inhibitors for cancer targets. ACS Med Chem Lett 2:662-666 (2011) [PubMed]  Article 
Target
Name:
MAP kinase-interacting serine/threonine-protein kinase 2
Synonyms:
GPRK7 | MAP kinase signal-integrating kinase 2 | MAP kinase-interacting serine/threonine-protein kinase 2 (MKNK2) | MAP kinase-interacting serine/threonine-protein kinase 2 (MnK2) | MAP-kinase interacting kinase 2 (MNK2) | MKNK2 | MKNK2_HUMAN | MNK2
Type:
Protein
Mol. Mass.:
51870.79
Organism:
Homo sapiens (Human)
Description:
Q9HBH9
Residue:
465
Sequence:
MVQKKPAELQGFHRSFKGQNPFELAFSLDQPDHGDSDFGLQCSARPDMPASQPIDIPDAKKRGKKKKRGRATDSFSGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWVQGCAPENTLPTPMVLQRNSCAKDLTSFAAEAIAMNRQLAQHDEDLAEEEAAGQGQPVLVRATSRCLQLSPPSQSKLAQRRQRASLSSAPVVLVGDHA
  
Inhibitor
Name:
BDBM50379077
Synonyms:
CHEMBL2012393
Type:
Small organic molecule
Emp. Form.:
C20H26O6
Mol. Mass.:
362.4168
SMILES:
COc1cc(OC)c2c(c1)\C=C\CC[C@H](O)[C@H](O)\C=C\C[C@H](C)OC2=O |r,t:11,19|
Structure:
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