Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50295422
Substrate
n/a
Meas. Tech.
ChEMBL_812735 (CHEMBL2019953)
Ki
12.9±n/a nM
Citation
 Laurini, E; Col, VD; Mamolo, MG; Zampieri, D; Posocco, P; Fermeglia, M; Vio, L; Pricl, S Homology Model and Docking-Based Virtual Screening for Ligands of the s1 Receptor. ACS Med Chem Lett 2:834-839 (2011) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Opioid receptor | Oprs1 | SGMR1_RAT | Sigma | Sigma non-opioid intracellular receptor 1 | Sigma opioid receptor | Sigma-1 | Sigmar1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25266.54
Organism:
RAT
Description:
Q9R0C9
Residue:
223
Sequence:
MPWAVGRRWAWITLFLTIVAVLIQAVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSHGHSGRYWAEISDTIISGTFHQWREGTTKSEVYYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALSDTIFSTQDFLTLFYTLRAYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50295422
Synonyms:
CHEMBL559979 | N-Benzyl-1-(4-chlorobenzyl)piperidine-4-carboxamide
Type:
Small organic molecule
Emp. Form.:
C20H23ClN2O
Mol. Mass.:
342.862
SMILES:
Clc1ccc(CN2CCC(CC2)C(=O)NCc2ccccc2)cc1
Structure:
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