Reaction Details Report a problem with these data
Target
Neuropeptide Y receptor type 5
Ligand
BDBM50380916
Substrate
n/a
Meas. Tech.
ChEMBL_813976 (CHEMBL2020488)
Ki
22±n/a nM
Citation
 Fichtner, M; Lee, E; Tomlinson, E; Scott, D; Cornelius, P; Patterson, TA; Carpino, PA Discovery and evaluation of spirocyclic derivatives as antagonists of the neuropeptide Y5 receptor. Bioorg Med Chem Lett 22:2738-43 (2012) [PubMed]  Article 
Target
Name:
Neuropeptide Y receptor type 5
Synonyms:
NPY-Y5 | NPY-Y5 receptor | NPY5-R | NPY5R | NPY5R_HUMAN | NPYR5 | NPYY5 | Neuropeptide Y receptor type 5 | Neuropeptide Y receptor type 5 ( NPY Y5) | Y5 receptor
Type:
Enzyme
Mol. Mass.:
50746.64
Organism:
Homo sapiens (Human)
Description:
Q15761
Residue:
445
Sequence:
MDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALLSSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAPERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLVSLIHCLHM
  
Inhibitor
Name:
BDBM50380916
Synonyms:
CHEMBL2016733
Type:
Small organic molecule
Emp. Form.:
C24H23FN4O3
Mol. Mass.:
434.4628
SMILES:
CN([C@H]1CC[C@@]2(CC1)OC(=O)c1ccccc21)C(=O)Nc1ccn(n1)-c1ccccc1F |r,wU:5.8,wD:2.1,(.28,-35.19,;.24,-36.74,;-1.11,-37.47,;-2.45,-36.7,;-3.79,-37.47,;-3.78,-39.01,;-2.45,-39.78,;-1.12,-39.01,;-3.62,-40.54,;-5.03,-41.16,;-5.35,-42.67,;-6.06,-40.02,;-7.59,-40.01,;-8.36,-38.69,;-7.6,-37.36,;-6.05,-37.35,;-5.28,-38.69,;1.56,-37.54,;1.62,-39.08,;2.89,-36.76,;4.18,-37.61,;5.63,-37.06,;6.59,-38.26,;5.74,-39.55,;4.25,-39.14,;6.5,-40.9,;5.7,-42.22,;6.45,-43.57,;8,-43.59,;8.79,-42.26,;8.03,-40.91,;8.82,-39.59,)|
Structure:
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