Reaction Details Report a problem with these data
Target
Neuropeptide Y receptor type 5
Ligand
BDBM50380917
Substrate
n/a
Meas. Tech.
ChEMBL_813976 (CHEMBL2020488)
Ki
849±n/a nM
Citation
 Fichtner, M; Lee, E; Tomlinson, E; Scott, D; Cornelius, P; Patterson, TA; Carpino, PA Discovery and evaluation of spirocyclic derivatives as antagonists of the neuropeptide Y5 receptor. Bioorg Med Chem Lett 22:2738-43 (2012) [PubMed]  Article 
Target
Name:
Neuropeptide Y receptor type 5
Synonyms:
NPY-Y5 | NPY-Y5 receptor | NPY5-R | NPY5R | NPY5R_HUMAN | NPYR5 | NPYY5 | Neuropeptide Y receptor type 5 | Neuropeptide Y receptor type 5 ( NPY Y5) | Y5 receptor
Type:
Enzyme
Mol. Mass.:
50746.64
Organism:
Homo sapiens (Human)
Description:
Q15761
Residue:
445
Sequence:
MDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALLSSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAPERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLVSLIHCLHM
  
Inhibitor
Name:
BDBM50380917
Synonyms:
CHEMBL2016734
Type:
Small organic molecule
Emp. Form.:
C22H20FN5O3
Mol. Mass.:
421.4243
SMILES:
Fc1ccccc1-n1ccc(NC(=O)NC2CCC3(CC2)OC(=O)c2ccncc32)n1 |(30.07,-39.3,;29.29,-40.63,;30.04,-41.97,;29.25,-43.3,;27.71,-43.28,;26.96,-41.94,;27.75,-40.61,;27,-39.27,;27.84,-37.98,;26.88,-36.77,;25.43,-37.32,;24.14,-36.47,;22.81,-37.26,;22.88,-38.8,;21.5,-36.45,;20.14,-37.19,;20.13,-38.73,;18.81,-39.49,;17.47,-38.72,;17.47,-37.18,;18.81,-36.42,;17.63,-40.26,;16.23,-40.88,;15.9,-42.39,;15.2,-39.73,;13.66,-39.73,;12.89,-38.4,;13.66,-37.07,;15.2,-37.07,;15.97,-38.4,;25.51,-38.86,)|
Structure:
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