Reaction Details Report a problem with these data
Target
Neuropeptide Y receptor type 5
Ligand
BDBM50380921
Substrate
n/a
Meas. Tech.
ChEMBL_813976 (CHEMBL2020488)
Ki
188±n/a nM
Citation
 Fichtner, M; Lee, E; Tomlinson, E; Scott, D; Cornelius, P; Patterson, TA; Carpino, PA Discovery and evaluation of spirocyclic derivatives as antagonists of the neuropeptide Y5 receptor. Bioorg Med Chem Lett 22:2738-43 (2012) [PubMed]  Article 
Target
Name:
Neuropeptide Y receptor type 5
Synonyms:
NPY-Y5 | NPY-Y5 receptor | NPY5-R | NPY5R | NPY5R_HUMAN | NPYR5 | NPYY5 | Neuropeptide Y receptor type 5 | Neuropeptide Y receptor type 5 ( NPY Y5) | Y5 receptor
Type:
Enzyme
Mol. Mass.:
50746.64
Organism:
Homo sapiens (Human)
Description:
Q15761
Residue:
445
Sequence:
MDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALLSSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAPERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLVSLIHCLHM
  
Inhibitor
Name:
BDBM50380921
Synonyms:
CHEMBL2016738
Type:
Small organic molecule
Emp. Form.:
C24H24FN5O3
Mol. Mass.:
449.4775
SMILES:
CN([C@H]1CC[C@@]2(CC1)Cc1cnccc1C(=O)O2)C(=O)Nc1ccn(n1)-c1ccccc1F |r,wU:2.1,5.19,(24.41,-6.79,;24.37,-8.33,;23.01,-9.07,;23.01,-10.61,;21.68,-11.37,;20.35,-10.6,;20.34,-9.07,;21.68,-8.3,;19.01,-9.83,;17.69,-10.6,;16.36,-9.83,;15.02,-10.59,;15.02,-12.14,;16.35,-12.9,;17.68,-12.14,;19.02,-12.91,;19.02,-14.45,;20.36,-12.14,;25.68,-9.14,;25.75,-10.68,;27.01,-8.36,;28.29,-9.2,;29.74,-8.65,;30.7,-9.86,;29.86,-11.14,;28.37,-10.74,;30.61,-12.49,;29.82,-13.81,;30.57,-15.15,;32.11,-15.18,;32.9,-13.84,;32.15,-12.51,;32.93,-11.18,)|
Structure:
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