Reaction Details Report a problem with these data
Target
Neuropeptide Y receptor type 5
Ligand
BDBM50380928
Substrate
n/a
Meas. Tech.
ChEMBL_813976 (CHEMBL2020488)
Ki
301±n/a nM
Citation
 Fichtner, M; Lee, E; Tomlinson, E; Scott, D; Cornelius, P; Patterson, TA; Carpino, PA Discovery and evaluation of spirocyclic derivatives as antagonists of the neuropeptide Y5 receptor. Bioorg Med Chem Lett 22:2738-43 (2012) [PubMed]  Article 
Target
Name:
Neuropeptide Y receptor type 5
Synonyms:
NPY-Y5 | NPY-Y5 receptor | NPY5-R | NPY5R | NPY5R_HUMAN | NPYR5 | NPYY5 | Neuropeptide Y receptor type 5 | Neuropeptide Y receptor type 5 ( NPY Y5) | Y5 receptor
Type:
Enzyme
Mol. Mass.:
50746.64
Organism:
Homo sapiens (Human)
Description:
Q15761
Residue:
445
Sequence:
MDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALLSSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAPERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLVSLIHCLHM
  
Inhibitor
Name:
BDBM50380928
Synonyms:
CHEMBL2016745
Type:
Small organic molecule
Emp. Form.:
C26H25N3O3
Mol. Mass.:
427.495
SMILES:
O=C(CC1CCC2(CC1)Cc1ccccc1C(=O)O2)Nc1cnc(cn1)-c1ccccc1 |(3.06,-22.71,;2.99,-21.17,;1.67,-20.37,;.32,-21.1,;.31,-22.64,;-1.01,-23.4,;-2.34,-22.63,;-2.35,-21.1,;-1.01,-20.33,;-3.68,-21.86,;-5.01,-22.63,;-6.33,-21.86,;-7.67,-22.62,;-7.67,-24.17,;-6.34,-24.94,;-5.01,-24.17,;-3.68,-24.95,;-3.67,-26.49,;-2.33,-24.17,;4.32,-20.39,;5.66,-21.14,;6.99,-20.37,;8.32,-21.14,;8.32,-22.69,;6.99,-23.46,;5.65,-22.69,;9.66,-23.46,;9.66,-25,;10.99,-25.77,;12.33,-25,;12.32,-23.45,;10.99,-22.69,)|
Structure:
Search PDB for entries with ligand similarity: