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Target
Muscarinic acetylcholine receptor M1
Ligand
BDBM50382138
Substrate
n/a
Meas. Tech.
ChEMBL_815523 (CHEMBL2025052)
EC50
1200±n/a nM
Citation
 Melancon, BJ; Gogliotti, RD; Tarr, JC; Saleh, SA; Chauder, BA; Lebois, EP; Cho, HP; Utley, TJ; Sheffler, DJ; Bridges, TM; Morrison, RD; Daniels, JS; Niswender, CM; Conn, PJ; Lindsley, CW; Wood, MR Continued optimization of the MLPCN probe ML071 into highly potent agonists of the hM1 muscarinic acetylcholine receptor. Bioorg Med Chem Lett 22:3467-72 (2012) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M1
Synonyms:
ACM1_HUMAN | CHRM1 | Cholinergic receptor, muscarinic 1 | Cholinergic, muscarinic M1
Type:
Protein
Mol. Mass.:
51442.54
Organism:
Homo sapiens (Human)
Description:
P11229
Residue:
460
Sequence:
MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
  
Inhibitor
Name:
BDBM50382138
Synonyms:
CHEMBL2024403
Type:
Small organic molecule
Emp. Form.:
C21H29N3O3
Mol. Mass.:
371.4733
SMILES:
CCOC(=O)N1C2CCC1CC(C2)N1CC[C@@H](C1)NC(=O)c1ccccc1 |r,TLB:3:5:11.10.12:7.8|
Structure:
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