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Target
D(3) dopamine receptor
Ligand
BDBM50382294
Substrate
n/a
Meas. Tech.
ChEMBL_816863 (CHEMBL2026134)
IC50
4.8±n/a nM
Citation
 Agai-Csongor, E; Domány, G; Nógrádi, K; Galambos, J; Vágó, I; Keseru, GM; Greiner, I; Laszlovszky, I; Gere, A; Schmidt, E; Kiss, B; Vastag, M; Tihanyi, K; Sághy, K; Laszy, J; Gyertyán, I; Zájer-Balázs, M; Gémesi, L; Kapás, M; Szombathelyi, Z Discovery of cariprazine (RGH-188): a novel antipsychotic acting on dopamine D3/D2 receptors. Bioorg Med Chem Lett 22:3437-40 (2012) [PubMed]  Article 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3_RAT | Dopamine D3 receptor | Drd3
Type:
Protein
Mol. Mass.:
49540.58
Organism:
Rattus norvegicus (Rat)
Description:
P19020
Residue:
446
Sequence:
MAPLSQISTHLNSTCGAENSTGVNRARPHAYYALSYCALILAIIFGNGLVCAAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPSICSISNPDFVIYSSVVSFYVPFGVTVLVYARIYIVLRQRQRKRILTRQNSQCISIRPGFPQQSSCLRLHPIRQFSIRARFLSDATGQMEHIEDKQYPQKCQDPLLSHLQPPSPGQTHGGLKRYYSICQDTALRHPSLEGGAGMSPVERTRNSLSPTMAPKLSLEVRKLSNGRLSTSLRLGPLQPRGVPLREKKATQMVVIVLGAFIVCWLPFFLTHVLNTHCQACHVSPELYRATTWLGYVNSALNPVIYTTFNVEFRKAFLKILSC
  
Inhibitor
Name:
BDBM50382294
Synonyms:
CHEMBL2024510
Type:
Small organic molecule
Emp. Form.:
C20H30F3N3O2S
Mol. Mass.:
433.531
SMILES:
CS(=O)(=O)N[C@H]1CC[C@H](CCN2CCN(CC2)c2cccc(c2)C(F)(F)F)CC1 |r,wU:5.4,wD:8.8,(-11.33,-16.02,;-9.99,-15.25,;-9.22,-13.91,;-10.76,-13.92,;-8.65,-16.02,;-7.32,-15.24,;-7.32,-13.7,;-5.99,-12.93,;-4.66,-13.7,;-3.32,-12.94,;-1.99,-13.71,;-.66,-12.95,;.67,-13.73,;2,-12.97,;2.01,-11.43,;.68,-10.65,;-.66,-11.41,;3.35,-10.67,;4.68,-11.45,;6.02,-10.69,;6.03,-9.15,;4.69,-8.37,;3.36,-9.13,;4.69,-6.83,;6.03,-6.06,;3.36,-6.05,;4.68,-5.28,;-4.66,-15.24,;-5.99,-16.01,)|
Structure:
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