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Target
D(3) dopamine receptor
Ligand
BDBM50382305
Substrate
n/a
Meas. Tech.
ChEMBL_816863 (CHEMBL2026134)
Ki
15.9±n/a nM
Citation
 Agai-Csongor, E; Domány, G; Nógrádi, K; Galambos, J; Vágó, I; Keseru, GM; Greiner, I; Laszlovszky, I; Gere, A; Schmidt, E; Kiss, B; Vastag, M; Tihanyi, K; Sághy, K; Laszy, J; Gyertyán, I; Zájer-Balázs, M; Gémesi, L; Kapás, M; Szombathelyi, Z Discovery of cariprazine (RGH-188): a novel antipsychotic acting on dopamine D3/D2 receptors. Bioorg Med Chem Lett 22:3437-40 (2012) [PubMed]  Article 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3_RAT | Dopamine D3 receptor | Drd3
Type:
Protein
Mol. Mass.:
49540.58
Organism:
Rattus norvegicus (Rat)
Description:
P19020
Residue:
446
Sequence:
MAPLSQISTHLNSTCGAENSTGVNRARPHAYYALSYCALILAIIFGNGLVCAAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPSICSISNPDFVIYSSVVSFYVPFGVTVLVYARIYIVLRQRQRKRILTRQNSQCISIRPGFPQQSSCLRLHPIRQFSIRARFLSDATGQMEHIEDKQYPQKCQDPLLSHLQPPSPGQTHGGLKRYYSICQDTALRHPSLEGGAGMSPVERTRNSLSPTMAPKLSLEVRKLSNGRLSTSLRLGPLQPRGVPLREKKATQMVVIVLGAFIVCWLPFFLTHVLNTHCQACHVSPELYRATTWLGYVNSALNPVIYTTFNVEFRKAFLKILSC
  
Inhibitor
Name:
BDBM50382305
Synonyms:
CHEMBL2024521
Type:
Small organic molecule
Emp. Form.:
C21H34N4O
Mol. Mass.:
358.5209
SMILES:
CN(C)C(=O)N[C@H]1CC[C@H](CCN2CCN(CC2)c2ccccc2)CC1 |r,wU:6.5,wD:9.9,(-10.22,-1.67,;-8.89,-2.44,;-8.89,-3.98,;-7.56,-1.67,;-7.56,-.13,;-6.22,-2.44,;-4.89,-1.67,;-4.89,-.13,;-3.56,.65,;-2.23,-.13,;-.9,.63,;.43,-.14,;1.77,.63,;3.09,-.15,;4.43,.61,;4.44,2.15,;3.11,2.92,;1.76,2.16,;5.78,2.91,;7.11,2.13,;8.44,2.88,;8.45,4.43,;7.12,5.21,;5.78,4.44,;-2.23,-1.67,;-3.56,-2.43,)|
Structure:
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