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Target
Proto-oncogene tyrosine-protein kinase Src
Ligand
BDBM50383382
Substrate
n/a
Meas. Tech.
ChEMBL_818068 (CHEMBL2033710)
Ki
1240±n/a nM
Citation
 Larson, ET; Ojo, KK; Murphy, RC; Johnson, SM; Zhang, Z; Kim, JE; Leibly, DJ; Fox, AM; Reid, MC; Dale, EJ; Perera, BG; Kim, J; Hewitt, SN; Hol, WG; Verlinde, CL; Fan, E; Van Voorhis, WC; Maly, DJ; Merritt, EA Multiple determinants for selective inhibition of apicomplexan calcium-dependent protein kinase CDPK1. J Med Chem 55:2803-10 (2012) [PubMed]  Article 
Target
Name:
Proto-oncogene tyrosine-protein kinase Src
Synonyms:
Calmodulin/Proto-oncogene tyrosine-protein kinase Src | Protein cereblon/Tyrosine-protein kinase SRC | Proto-oncogene c-Src | Proto-oncogene tyrosine-protein kinase Src (c-Src) | SRC | SRC1 | SRC_HUMAN | Tyrosine-protein kinase Src (SRC) | V-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | c-Src | p60-Src | pp60c-src
Type:
Protein
Mol. Mass.:
59838.60
Organism:
Homo sapiens (Human)
Description:
P12931
Residue:
536
Sequence:
MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
  
Inhibitor
Name:
BDBM50383382
Synonyms:
CHEMBL2030556 | CHEMBL2069948 | US10172858, Table 2.9 | US10544104, Compound 26 | US11247972, Compound 26 | US9765037, Compound 26 | US9828378, # 9
Type:
Small organic molecule
Emp. Form.:
C16H15ClN6
Mol. Mass.:
326.784
SMILES:
CC(C)n1nc(-c2cc3c(Cl)cccc3[nH]2)c2c(N)ncnc12
Structure:
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