Reaction Details Report a problem with these data
Target
Histamine H3 receptor
Ligand
BDBM50383442
Substrate
n/a
Meas. Tech.
ChEMBL_818296 (CHEMBL2034344)
Ki
2.4±n/a nM
Citation
 Xiao, D; Palani, A; Sofolarides, M; Aslanian, R; West, RE; Williams, SM; Wu, RL; Hwa, J; Sondey, C; Lachowicz, J; Korfmacher, WA Fused bicycles as arylketone bioisosteres leading to potent, orally active thiadiazole H3 antagonists. Bioorg Med Chem Lett 22:3354-7 (2012) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
HH3R | HRH3_MOUSE | Hrh3
Type:
PROTEIN
Mol. Mass.:
48560.37
Organism:
Mus musculus
Description:
ChEMBL_988451
Residue:
445
Sequence:
MERAPPDGLMNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCASSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAGPEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVETGEAGLGGGSGGGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHGSLEQCWK
  
Inhibitor
Name:
BDBM50383442
Synonyms:
CHEMBL2031602
Type:
Small organic molecule
Emp. Form.:
C19H25N7S
Mol. Mass.:
383.514
SMILES:
Cc1nnc2ccc(cn12)-c1nnc(s1)N1CCC(CC1)N1CCCCC1
Structure:
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