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Target
Arachidonate 5-lipoxygenase-activating protein
Ligand
BDBM50383902
Substrate
n/a
Meas. Tech.
ChEMBL_819515 (CHEMBL2033320)
IC50
5.8±n/a nM
Citation
 Chu, L; Armstrong, HM; Chang, LL; Cheng, AF; Colwell, L; Cui, J; Evans, J; Galka, A; Goulet, MT; Hayes, N; Lo, J; Menke, J; Ok, HO; Ondeyka, DL; Patel, M; Quaker, GM; Sings, H; Witkin, SL; Zhao, A; Ujjainwalla, F Evaluation of endo- and exo-aryl-substitutions and central scaffold modifications on diphenyl substituted alkanes as 5-lipoxygenase activating protein inhibitors. Bioorg Med Chem Lett 22:4133-8 (2012) [PubMed]  Article 
Target
Name:
Arachidonate 5-lipoxygenase-activating protein
Synonyms:
5-lipoxygenase activating protein | 5-lipoxygenase-activating protein (FLAP) | 5-lipoxygenase/FLAP | AL5AP_HUMAN | ALOX5AP | FLAP | MK-886-binding protein
Type:
Enzyme
Mol. Mass.:
18159.90
Organism:
Homo sapiens (Human)
Description:
P20292
Residue:
161
Sequence:
MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNCVDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIILFLFLMSVAGIFNYYLIFFFGSDFENYIKTISTTISPLLLIP
  
Inhibitor
Name:
BDBM50383902
Synonyms:
CHEMBL2031456
Type:
Small organic molecule
Emp. Form.:
C35H31N3O2
Mol. Mass.:
525.6395
SMILES:
O=C(Nc1cccnc1)c1ccc(OCc2ccc3ccccc3n2)cc1[C@@]1(C[C@H]2CC[C@H]1C2)c1ccccc1 |r,TLB:34:27:31.30:33,THB:26:27:31.30:33|
Structure:
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