Reaction Details Report a problem with these data
Target
Peptide deformylase
Ligand
BDBM50383999
Substrate
n/a
Meas. Tech.
ChEMBL_819736 (CHEMBL2034166)
IC50
0.86±n/a nM
Citation
 Axten, JM; Medina, JR; Blackledge, CW; Duquenne, C; Grant, SW; Bobko, MA; Peng, T; Miller, WH; Pinckney, T; Gallagher, TF; Kulkarni, S; Lewandowski, T; Van Aller, GS; Zonis, R; Ward, P; Campobasso, N Acylprolinamides: a new class of peptide deformylase inhibitors with in vivo antibacterial activity. Bioorg Med Chem Lett 22:4028-32 (2012) [PubMed]  Article 
Target
Name:
Peptide deformylase
Synonyms:
DEF_STAAM | PDF | Polypeptide deformylase | def | def1 | pdf1
Type:
Enzyme
Mol. Mass.:
20556.80
Organism:
Staphylococcus aureus
Description:
P68825
Residue:
183
Sequence:
MLTMKDIIRDGHPTLRQKAAELELPLTKEEKETLIAMREFLVNSQDEEIAKRYGLRSGVGLAAPQINISKRMIAVLIPDDGSGKSYDYMLVNPKIVSHSVQEAYLPTGEGCLSVDDNVAGLVHRHNRITIKAKDIEGNDIQLRLKGYPAIVFQHEIDHLNGVMFYDHIDKNHPLQPHTDAVEV
  
Inhibitor
Name:
BDBM50383999
Synonyms:
CHEMBL2032137
Type:
Small organic molecule
Emp. Form.:
C24H34N4O5
Mol. Mass.:
458.5506
SMILES:
ON(C[C@@H](CC1CCCC1)C(=O)N1CCC[C@H]1C(=O)NC(=O)NCCc1ccccc1)C=O |r|
Structure:
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