Reaction Details Report a problem with these data
Target
Myeloblastin
Ligand
BDBM50384111
Substrate
n/a
Meas. Tech.
ChEMBL_819862 (CHEMBL2034576)
IC50
1400±n/a nM
Citation
 Santana, AB; Lucas, SD; Gonçalves, LM; Correia, HF; Cardote, TA; Guedes, RC; Iley, J; Moreira, R N-Acyl and N-sulfonyloxazolidine-2,4-diones are pseudo-irreversible inhibitors of serine proteases. Bioorg Med Chem Lett 22:3993-7 (2012) [PubMed]  Article 
Target
Name:
Myeloblastin
Synonyms:
Leukocyte proteinase 3 | MBN | PRTN3 | PRTN3_HUMAN
Type:
PROTEIN
Mol. Mass.:
27816.30
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1463425
Residue:
256
Sequence:
MAHRPPSPALASVLLALLLSGAARAAEIVGGHEAQPHSRPYMASLQMRGNPGSHFCGGTLIHPSFVLTAAHCLRDIPQRLVNVVLGAHNVRTQEPTQQHFSVAQVFLNNYDAENKLNDVLLIQLSSPANLSASVATVQLPQQDQPVPHGTQCLAMGWGRVGAHDPPAQVLQELNVTVVTFFCRPHNICTFVPRRKAGICFGDSGGPLICDGIIQGIDSFVIWGCATRLFPDFFTRVALYVDWIRSTLRRVEAKGRP
  
Inhibitor
Name:
BDBM50384111
Synonyms:
CHEMBL2029556
Type:
Small organic molecule
Emp. Form.:
C13H13NO5
Mol. Mass.:
263.246
SMILES:
COc1ccc(cc1)C(=O)N1C(=O)OC(C)(C)C1=O
Structure:
Search PDB for entries with ligand similarity: